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The major locus for multifactorial nonsyndromic cleft lip maps to mouse Chromosome 11 总被引:4,自引:0,他引:4
Cleft lip with or without cleft palate, CL(P), a common human birth defect, has a genetically complex etiology. An animal model with a similarly complex genetic basis is established in the A/WySn mouse strain, in which 20% of newborn have CL(P). Using a newly created congenic strain, AEJ.A, and SSLP markers, we have mapped a major CL(P)-causing gene derived from the A/WySn strain. This locus, here named clf1 (cleft lip) maps to Chromosome (Chr) 11 to a region having linkage homology with human 17q21-24, supporting reports of association of human CL(P) with the retinoic acid receptor alpha (RARA) locus. 相似文献
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The Species Survival Commission (SSC) of IUCN—the World Conservation Union is the largest, most comprehensive and diverse professional conservation network in existence today. It brings together over 6000 volunteers from more than 160 countries to contribute to the conservation of biological diversity by developing and executing programmes to study, save, restore, and manage wisely species and their habitats. The SSC is organized primarily along taxonomic lines, with members distributed in 96 Specialist Groups focusing on distinct groups of species. These groups are a source of the most current and expert information on the conservation status and priorities for action for species in the wild. As such, they provide an invaluable resource in setting priorities for captive propagation and in linking ex situ actions. In addition, the SSC has five disciplinary Specialist Groups that provide expertise to both the zoo community and field conservationists in areas such as reintroductions, veterinary medicine, captive breeding as a conservation tool, and the impact of invasive species on native flora and fauna. The effectiveness of the SSC is greatly enhanced by the close connections within its network between zoo professionals, academic scientists, field conservationists, and managers of natural resources. Challenges to the SSC currently include better information management, organization at the national level, and extending coverage in areas such as marine biodiversity. 相似文献
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CLARE D. FITZGIBBON 《Mammal Review》1995,25(1-2):19-30
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Purification and properties of the endocellular β-glucosidase of Candida cacaoi Buckley and Van Uden CBS 2020 总被引:1,自引:1,他引:0
D. Drider P. Pommares P. Chemardin A. Arnaud P. Galzy 《Journal of applied microbiology》1993,74(4):473-479
D. DRIDER, P. POMMARES, P. CHEMARDIN, A. ARNAUD AND P. GALZY. 1993. The endocellular enzyme β-glucosidase of Candida cacaoi was purified by ion-exchange chromatography and gel filtration. The molecular weight was 220 ± 10 kDa; its optimum pH was between 4 and 5.5 and its optimum temperature was 60C. This enzyme was active against soluble glucosides tested with β(1–2), β(1–3), β(1–4) and even α(1–4) and α(1–6) and was inhibited by D-glucono-δ-lactone. The enzyme was constitutive but its synthesis was repressed by glucose. 相似文献
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